BRCA 1 - BRCA 2 cause early breast cancer

on with 0 comments

The Correct answer is B

Accommodating risk: Responses to BRCA1/2 genetic testing of women who have had cancer [An article from: Social Science & Medicine]BRCA 1 & BRCA 2 cause early breast cancer (dominant inheritance). ATM gene causes breast cancer – DNA repair disorder (recessive inheritance). P53 mutations are found in ~60% of all human cancer types including breast. Note Li-Frumeni syndrome – vulnerable to a wide range of cancers, 50% likelihood of Ca by age 30 & 90% by age 65. The precise function of p53 is unknown – may act as DNA policeman to prevent transcription & replication of unstable DNA.

Bcl-2 is involved in the control of apoptosis (programmed cell death) & prevents the p53 mediated destruction of cells with damaged DNA. It also may prevent the death of cells severely damaged by chemotherapy, & mediates drug resistance & contributes to neoplasia by this mechanism rather than promoting aberrant cell growth. It was first identified because of an association with follicular lymphoma.




Post a Comment

Is there something you wish to add? Have something to say? Feel free to leave a comment.