Linkage analysis methods

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Linkage Disequilibrium and Association Mapping: Analysis and Applications (Methods in Molecular Biology)The Correct Answer is B

Linkage analysis methods all rest on the biological phenomenon of recombination of homologous chromosomes. During meiosis homologous chromosomes pair up and exchange material. The probability of a recombination event occurring between loci far apart on a single chromosome is larger than for loci closer together. Hence, alleles at loci near each other are generally inherited (or co-segregate) together, making it possible to follow transmission from generation to generation at unknown loci by using alleles at neighbouring loci (i.e. the neighbouring locus alleles act as surrogates for the presence of alleles at other loci).




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